Little’s five hits led all players, while teammate Bryan Peck had four hits and Greg Norton and Walt McKeel each had three.
The White Sox produced 10 runs on 11 hits, including four RBI, three runs scored and two hits from Jason Dellaero, who played shortstop before taking a turn on the mound.
Tony Graffanino, Aaron Rowand and Josh Paul also had two hits apiece for the White Sox.
Chicago sent five hurlers to the mound and each gave up at least one run. Dellaero and Jason Stumm, who took the loss, each surrendered a team-high six runs. Starter Josh Stewart fared the best of the five, throwing three innings and giving up one run on five hits.
Reliever Chris Buglovsky earned the win despite giving up six runs – four of which were earned – for the Rockies. None of the nine pitchers used in the game threw more than three innings, and Colorado reliever Brian Fuentes was the only one to pitch a scoreless outing, throwing one inning without allowing a hit.